Survival Noninferiority is a program to calculate either estimates of sample size or power for noninferiority studies. Exponential distributions are assumed and are specified using the ratio of the hazard for the experimental treatment to the hazard for the standard treatment. The ratio of hazard rates describing noninferiority is defined in the same way.

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User Input

Program Output

Alpha (one-sided)

Competing Risk

Proportion in Experimental Sample

Accrual Period

Follow-up Period

Power

Sample Size

Noninferiority Margin (Hazard Ratio Between Standard and Experimental Arm (Under H0))

Hazard Rate in Standard Arm

Median Survival in Standard Arm

Survival Probability in Standard Arm

at Time

Hazard Ratio (Under Ha)

Power

Sample Size

Hazard Rate in Standard Arm

Hazard Rate in Experimental Arm (Under H0)

Hazard Rate in Experimental Arm (Under Ha)

Median Survival in Standard Arm

Median Survival in Experimental Arm (Under H0)

Median Survival in Experimental Arm (Under Ha)